产品货号：
Z10068
中文名称：
ABIN3/TNIP3抗体
英文名称：
Anti-ABIN3/TNIP3 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ABIN3/TNIP3 Antibody |
| 指标别名 | LIND;ABIN-3;ABIN3;LIND;TNFAIP3-interacting protein 3;A20-binding inhibitor of NF-kappa-B activation 3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,IHC |
| 基因名称 | TNIP3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | ABIN3 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ABIN3.The immunogen is located within the last 50 amino acids of ABIN3. |
| 计算分子量 | 39kDa |
| 成分 | ABIN3 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | ABIN3 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | The nuclear factor NF-百B plays key roles in development and immunity.ABIN3 (A20-binding inhibitor of NF-百B activation 3),also known as TNFAIP3-interacting protein 3 (TNIP3),is a novel negative feedback regulator of LPS-induced NF-百B activation.ABIN3 is a 39kDa protein that negatively regulates NF-百B activation in response to TNF and LPS.ABIN3 is highly expressed in brain,thymus,lymph node,lung and fetal liver,with low expression in kidney,bone marrow.Through its interaction with A20,ABIN3 interferes with TRAF2-mediated transactivation signals and NF-百B inhibition is mediated by the ABIN-homology domain 2.ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone.Enhanced expression of ABIN3 in monocytes is associated with sepsis.Thus,ABIN3 is an IL-10-induced gene product capable of attenuating NF-百B in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions.At least four isoforms of ABIN3 are known to exist. |
| Uniprot ID | Q96KP6 |
| 基因名全称 | TNFAIP3 interacting protein 3 |
| 蛋白名全称 | TNFAIP3 interacting protein 3 |
| 推荐稀释比 | ABIN3 antibody can be used for detection of ABIN3 by Western blot at 1μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.Antibody validated:Western Blot in human samples and Immunohistochemistry in mouse samples.All other applications and species not yet tested. |
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